Biological mechanisms behind clozapine-induced agranulocytosis
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Exploring Off-Targets and Off-Systems for Adverse Drug Reactions via Chemical-Protein Interactome — Clozapine-Induced Agranulocytosis as a Case Study
In the era of personalized medical practice, understanding the genetic basis of patient-specific adverse drug reaction (ADR) is a major challenge. Clozapine provides effective treatments for schizophrenia but its usage is limited because of life-threatening agranulocytosis. A recent high impact study showed the necessity of moving clozapine to a first line drug, thus identifying the biomarkers ...
متن کاملInhibition of p38-mitogen-activated protein kinase may protect from clozapine-induced agranulocytosis.
Despite the clinical advantages of clozapine in the treatment of otherwise therapy-resistant schizophrenia, continuous administration results in neutropenia and life-threatening clozapine-induced agranulocytosis (CA) in about 2.2% and 0.8% of patients, respectively (Atkin et al. 1996). The aetiopathogenesis of these haematogeneous side effects is still uncertain, but there is increasing evidenc...
متن کاملگزارش یک مورد آگرانولوسیتوز بدنبال مصرف کلوزاپین
Introduction : clozapine is the first effective antipsychotic drug with the least extra pyramidal side effects and more agranulocytosis than other standard neuroleptics. Granolocytopenia or agranulocytosis occurs in 1 to 2 percent of all patients treated with clozapine. agranulocytosis due to clozapine is a fatal disorder that requires immediate clinical intervention. Method : this paper re...
متن کاملClozapine-induced Agranulocytosis and Use of G-csf
Use of clozapine is attended with the serious though rare risk of agranulocytosis. Clozapineinduced agranulocytosis is reversible with the use of cytokines like granulocyte-colony stimulating factor (G-CSF). Reports of the haematological complication of clozapine have not been forthcoming from India though it has been in use for nearly three years. This report is on an young patient who develop...
متن کاملLate Onset Agranulocytosis with Clozapine Associated with HLA DR4 Responding to Treatment with Granulocyte Colony-stimulating Factor: A Case Report and Review of Literature.
Agranulocytosis as a side effect of clozapine has been reported to be associated with initial phases of treatment, i.e., first six months. Agranulocytosis with clozapine during the initial phases of treatment has been linked to genetic vulnerability in the form of variations in the human leukocyte-antigen haplotypes. However, there is limited literature on late onset agranulocytosis with clozap...
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تاریخ انتشار 2009